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New champions, newest first

LockeZaahenYunaraMelAmbessaAuroraSmolderHweiBriarNaafiriMilioK'SanteNilahBel'VethRenata GlascZeriVexAkshanGwenViegoRellSeraphineSamiraYoneLilliaSettApheliosSennaQiyanaYuumiSylasNeekoPykeKai'SaZoeOrnnKaynRakanXayahCamilleIvernKledTaliyahAurelion SolJhin

New items

Items that are gone

• Hunter's Talisman
• Hunter's Machete
• Brawler's Gloves
• Kircheis Shard
• Hunter's Potion
• Corrupting Potion
• Vision Ward
• Ruby Sightstone
• Sightstone
• Raptor Cloak
• Eye of the Watchers
• Eye of the Oasis
• Eye of the Equinox
• Abyssal Scepter
• Catalyst the Protector
• Frozen Mallet
• Chalice of Harmony
• Giant Slayer
• Jaurim's Fist
• Ohmwrecker
• Banner of Command
• Talisman of Ascension
• Frost Queen's Claim
• Nomad's Medallion
• Targon's Brace
• Frostfang
• Stinger
• Aegis of the Legion
• Boots of Mobility
• Ancient Coin
• Spellthief's Edge
• Sweeping Lens (Trinket)
• Face of the Mountain
• Zz'Rot Portal
• Stalker's Blade
• Tracker's Knife
• Skirmisher's Sabre
• Righteous Glory

Renamed items

• Boots of Speed is now Boots
• The Dark Seal is now Dark Seal
• Glacial Shroud is now Glacial Buckler
• Ninja Tabi is now Plated Steelcaps
• Zeke's Harbinger is now Zeke's Convergence
• Sunfire Cape is now Sunfire Aegis
• The Black Cleaver is now Black Cleaver
• The Bloodthirster is now Bloodthirster
• Bilgewater Cutlass is now Scout's Slingshot
• Hextech Revolver is now Hextech Alternator
• Will of the Ancients is now Hextech Rocketbelt
• Blade of the Ruined King is now Blade of The Ruined King
• Athene's Unholy Grail is now Armored Advance
• Mikael's Crucible is now Mikael's Blessing
• Relic Shield is now Terminus
• Warding Totem (Trinket) is now Stealth Ward
• Oracle Alteration is now Oracle Lens

From Riot's game data, comparing patch 5.24 with 16.22. It covers champions and items. It says nothing about map or gameplay changes.