No settled build

1. TaliyahMid2,990 games36% pick53.2% winSummon Aery1,065 games31% pick51.7% winStormraider's Surge924 games25% pick48.0% winDeathfire Touch741 games
2. FioraTop3,632 games37% pick48.3% winPress the Attack1,360 games28% pick51.2% winHail of Blades1,025 games28% pick51.9% winConqueror1,010 games
3. GnarTop4,489 games45% pick50.7% winFleet Footwork2,022 games42% pick48.8% winLethal Tempo1,897 games10% pick41.7% winGrasp of the Undying463 games
4. JayceTop7,432 games47% pick49.3% winStormraider's Surge3,507 games31% pick48.6% winGrasp of the Undying2,308 games21% pick46.9% winConqueror1,569 games
5. Bel'VethJungle3,164 games50% pick51.3% winLethal Tempo1,580 games33% pick54.1% winPress the Attack1,032 games17% pick54.4% winConqueror537 games
6. PantheonTop4,104 games50% pick51.5% winConqueror2,053 games34% pick51.1% winStormraider's Surge1,411 games15% pick52.1% winPress the Attack633 games
7. Kha'ZixJungle7,962 games50% pick50.8% winFirst Strike4,020 games27% pick47.6% winDark Harvest2,186 games22% pick51.8% winStormraider's Surge1,756 games
8. KaynJungle6,863 games51% pick49.4% winDark Harvest3,483 games42% pick50.3% winConqueror2,901 games5% pick51.3% winHail of Blades310 games
9. SwainSupport3,876 games51% pick46.2% winElectrocute1,991 games49% pick47.2% winConqueror1,885 games
10. TalonJungle6,572 games52% pick52.6% winFleet Footwork3,423 games25% pick50.4% winFirst Strike1,669 games7% pick55.0% winConqueror431 games
11. VeigarMid3,516 games53% pick51.1% winFirst Strike1,869 games37% pick48.0% winArcane Comet1,291 games8% pick295 gamesElectrocute
12. KassadinMid3,377 games54% pick50.8% winElectrocute1,834 games31% pick49.4% winFirst Strike1,062 games13% pick53.7% winDeathfire Touch441 games
13. SylasMid10,765 games55% pick48.9% winConqueror5,956 games45% pick49.1% winElectrocute4,809 games
14. Cho'GathTop2,703 games56% pick50.5% winHail of Blades1,508 games43% pick52.4% winGrasp of the Undying1,164 games1% pick31 gamesPress the Attack
15. Nunu & WillumpJungle1,743 games56% pick51.9% winStormraider's Surge978 games29% pick50.2% winDark Harvest500 games10% pick166 gamesElectrocute
16. TryndamereTop3,379 games57% pick48.6% winHail of Blades1,913 games30% pick49.1% winLethal Tempo1,021 games13% pick46.8% winGrasp of the Undying434 games
17. ZaahenTop4,279 games57% pick51.3% winConqueror2,426 games26% pick50.5% winGrasp of the Undying1,100 games18% pick51.7% winHail of Blades753 games
18. KayleTop2,398 games58% pick54.6% winPress the Attack1,386 games34% pick54.7% winLethal Tempo814 games8% pick198 gamesFleet Footwork
19. Miss FortuneADC15,374 games58% pick50.6% winPress the Attack8,925 games40% pick51.3% winFirst Strike6,210 games1% pick174 gamesDeathfire Touch
20. LissandraMid8,636 games58% pick51.7% winElectrocute5,014 games42% pick51.2% winArcane Comet3,622 games
21. KatarinaMid9,097 games58% pick52.5% winElectrocute5,282 games37% pick49.4% winConqueror3,368 games5% pick49.7% winDark Harvest447 games
22. ViegoJungle10,576 games59% pick49.9% winConqueror6,220 games41% pick51.6% winHail of Blades4,297 games1% pick59 gamesPress the Attack
23. ThreshSupport21,966 games59% pick51.0% winAftershock12,986 games20% pick52.1% winGuardian4,499 games20% pick49.7% winGlacial Augment4,461 games
24. ZedMid11,273 games59.7% pick51.0% winFirst Strike6,725 games33% pick47.1% winElectrocute3,672 games8% pick47.6% winConqueror876 games

Summed from each champion's matchup guides, patch 16.22. Champions with fewer than 5 guides are left out.